Wound infection continues to be challenging for people with a wound, which can lead to protracted wound healing, multiple health service visits and increased hospital admission duration.  The newly released edition of Wound Infection in Clinical Practice 2022 is an update from the previous document published in 2016.  Advances in research and clinical practice relating to the wound environment, risk factors for infection, biofilm, antimicrobial resistance, and new technologies for identification and management of wound infection have been incorporated in this update. The update provides an opportunity to explore contemporary advances in wound infection knowledge and practice.