Debunking myths around Prontosan®

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Debunking myths around Prontosan®

Prontosan® has been around for many years, yet there are some misconceptions around the use of Prontosan®.

Myth: Prontosan® Wound Gel/Gel X is the same as other Hydrogels

There is some misconception that Hydrogels have the same mode of action as Prontosan® Wound Gel/Gel X.

The purpose of a Hydrogel is to provide moisture and hydration to the wound. Where Prontosan® Gel and Prontosan® Gel X is different, it includes an antimicrobial and is indicated for cleansing, moistening and decontamination of acute, chronic and infected dermal wounds and burns. Prontosan® Wound Gel/Gel X acts as an effective barrier to reduce colonisation and to decontaminate the wound bed between dressing changes, therefore has continued action to remove and prevent reconstitution of the biofilm.  However, not only does Prontosan® Wound Gel/Gel X prevent the reformation of biofilm, it maintains a moist wound healing environment conducive to natural healing.1

Proteins might build up a resistance to Prontosan®

There is no reported antimicrobial resistance to PHMB.

Prontosan’s mode of action can be described as a non-specific electrostatic interaction with the bacterial cell wall. The attachment of polyhexanide to the bacterial cell wall results in a disorganisation of the biological structure of the bacteria.  The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains.  Thus, PHMB is particularly suitable and useful in the struggle against multi-drug resistant bacteria.2


In fact the opposite is true.  Prontosan is especially designed for the long term treatment of hard-to-heal wounds.  There is no limit for the treatment duration with Prontosan Wound Irrigation Solution. 

Efficacy and cytotoxicity vary significantly between existing cleansing solutions.  Generally, increasing antimicrobial activity is associated with decreasing cell viability.3

In a study on the toxic side effects of clinically used antiseptics, Prontosan has shown higher efficacy and has demonstrated less toxicity against 4 other typically used skin antiseptics on the market.4

It is to be reminded that Cytotoxicity of different solutions shall be closely monitored and used under the control of healthcare professional to avoid any adverse events.



1. Prontosan® Wound Gel/Gel X Instruction for Use.

2. 2010-Kaehn-PHMB-A-Safe-and-Highly-Effective-Biocide.

3. Safety and efficacy profiles of different commercial sodium hypochlorite/hypochlorous acid solutions (NaCIO/HCIO): antimicrobial efficacy, cytotoxic impact and physiochemical parameters in vitro. Journal of Antimicrobial Chemotherapy, 2019.Anna-Lena Severing, Julian-Dario Rembe, Verna Koester and Ewa k. Stuermer.

4. Evaluation of toxic side effects of clinically used antiseptics in vitro. Hirsch T, Koerber A, Jacobsen F et al. J Surg Res 2010; 164(2); 344-350.