Adjustable gravitational valve for the treatment of hydrocephalus
M.blue® is the essence of over 28 years of experience with valve technology for the treatment of hydrocephalus and is based on feedback from numerous doctors and patients worldwide.
M.blue® focuses on the patient's active time, which is mostly spent sitting or upright and takes up about 2/3 of a day. This is where the greatest risk of positional overdrainage exists.
With its adjustable gravitational unit and a wide adjustment range of 0-40 cmH2O, the valve can be adapted to the individual requirements in life with hydrocephalus: mobility, growth and changes in the course of the disease , , , 
The M.blue® is a position-dependent hydrocephalus valve. It consists of an adjustable gravitational unit and a fixed differential pressure unit.
Particularly challenging and difficult forms of hydrocephalus require a much higher degree of flexibility in treatment. This is what the M.blue® plus stands for: a combination of adjustable gravitational unit and adjustable differential pressure unit (proGAV® 2.0).
- ONE valve for the special requirements of a life with hydrocephalus: mobility, growth, changes in the course of disease , , , 
- 2 in 1 technology: adjustable gravitational unit combined with fixed differential pressure unit in one valve
- Unique uncompromising pressure adaption to fulfill individual patient needs , 
- Smallest adjustable gravitational valve worldwide
- Efficient protection against over drainage through individually and continuously adjustable opening pressure from 0-40 cmH2O ,  , 
- MRI-compatible up to 3 Tesla - no X-ray control after MRI necessary, no additional radiation exposure for the patient , 
- Safe from unintentional adjustment by everyday magnets such as smartphones, toys, induction cookers or safety barriers at the airport , 
- Innovative M.blue plus® Instruments for M.blue® and proGAV® 2.0
- Intuitive, secure and comfortable adjustment
- Precision engineering
- Robust and durable: made of titanium
- Length single valve: 25 mm
- Diameter: 16,6 mm
- Height: 4,2 mm
- Material: Titanium
Because the opening pressure of the valve depends on the position of the patient, M.blue® must be implanted parallel to the body axis.
Treatment of Hydrocephalus
 2010, Mar, Sprung C., Schlosser H. G., Lemcke J., Meier U., Messing-Junger M., Trost H. A., Weber F., Schul C., Rohde V., Ludwig H. C., Hopfner J., Sepehrnia A., Mirzayan M. J. and Krauss J. K.: "The adjustable proGAV shunt: a prospective safety and reliability multicenter study", Neurosurgery 66(3): 465-474
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 NPH-Leitlinien der DGN 2018
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 2014, Tschan C. A., Antes S., Huthmann A., Vulcu S., Oertel J. and Wagner W.: "Overcoming CSF overdrainage with the adjustable gravitational valve proSA", Acta Neurochir (Wien) 156(4): 767-776,
 2017, May, Alavi S.,Schulz M., Schaumann A., Schwarz K. and Thomale U. W.: "Valve exchange towards an adjustable differential pressure valve with gravitational unit, clinical outcome of a single-center study", Childs Nerv Syst 33(5): 759-765
 2016, May, Gebert A. F., Schulz M., Schwarz K. and Thomale U. W.: "Longterm survival rates of gravityassisted, adjustable differential pressure valves in infants with hydrocephalus", J Neurosurg Pediatr 17(5): 544-551
 2016, May 15, Miyake H.: "Shunt Devices for the Treatment of Adult Hydrocephalus: Recent Progress and Characteristics", Neurol Med Chir (Tokyo)
 2017, Pierson M. J., Wehrmann D., Albers J. A., El Tecle N. E., Costa D. and Elbabaa S. K.: "Programmable shunt valve interactions with osseointegrated hearing devices", J Neurosurg Pediatr 19(4): 384-3
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 2020, Gutowski P., Golz L., Rot S., Lemcke J. and Thomale U. W.:"Gravitational shunt valves in hydrocephalus to challenge the sequelae of over-drainage", Expert Rev Med Devices 17(11): 1155-1168