Biofilm A major issue in wound healing

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The presence of biofilm is reportedly present in 60-100% of non-healing wounds (WUWHS Biofilm Position Paper, 2016). While the role that biofilm plays in the chronicity of wounds is still not fully investigated, it is becoming widely accepted that hard-to-heal wounds contain biofilm - and somehow its presence delays or prevents healing. 

Therefore the management of biofilm in chronic wounds is rapidly becoming a primary object of wound care. 

Biofilm - a major issue in wound healing

NEW: Biofilm Position Paper

Wounds International elaborated this position document in collaboration with the World Union of Wound Healing Societies (WUWHS). In this paper leading clinicians look at the role biofilm plays in delayed wound healing, the management of biofilm in practice as well as the understanding of these bacterial communities.

Biofilm Management combined with antimicrobial effectiveness

Graphic adapted from "International Wound Infection Institute (IWII). Wound infection in clinical practice. Wounds International 2016."

Acute and chronic wounds have a tendency to become infected, which compromises the normal healing process. This leads to a greater burden on the health systems, long-term disabilities and an overall reduction in the patients’ quality of life.

The wound infection continuum1 describes the different stages of how microbes impact a wound and consequently shows when antimicrobials are indicated and when not. This helps wound care practitioners to find the best strategy to prevent, diagnose and manage wound infections.

Get to know our unique therapy concept that covers all stages of the wound infection continuum: Prontosan® to prevent the formation of biofilm and decrease the bacterial burden2 to prevent wound infection.3

Prontosan® - Wound bed preparation taken seriously

Wound infections are caused by the deposit and profileration of microorganisms in the surgical site of a susceptible host. There are numerous ways microorganisms can enter the wound bed. The infection can result in sepsis when bacteria spreads into the blood stream. If not actively treated, a sepsis can progress to multi-organ failures with a potentially lethal outcome.

The main objective is to prevent infections rather than to treat them. Learn more about wound bed preparation.

Related Documents & Evidence

Description Document Link
RCT Study Bellingeri et al.
pdf (143.6 KB)
Study Summary: RCT Study Bellingeri et al.
pdf (99.0 KB)


1. International Wound Infection Institute (IWII). Wound infection in clinical practice. Wounds International 2016. (accessed on 14 October 2020)

2. To, E The effectivness of PHMB agents for the treatment of chronic wounds: A systematic review, Advance wound healing, 2016.

3. Moore, M 0.1% Polyhexanide-Betaine Solution as an Adjuvant in a Case-Series of Chronic Wounds, Surg Technology International, 2016